A stereoselective α-fucosylation reaction using 1-hydroxy 2,3,4-trio- benzyl-L-fucose donor for the practical synthesis of selectin blocker

Takao Kiyoi; Hirosato Kondo

doi:10.1016/S0960-894X(98)00516-2

A stereoselective α-fucosylation reaction using 1-hydroxy 2,3,4-trio- benzyl-L-fucose donor for the practical synthesis of selectin blocker

Takao Kiyoi, Hirosato Kondo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 1-hydroxy 2,3,4-tri-O-benzyl-L-fucose donor affords a high stereoselectivity of glycosylation in the presence of TMSOTf and is a very useful substrate for the preparation of an α-L-fucosyl dipeptide in a stereoselective manner. The donor will be a key component in the preparation of an attractively biological selectin blocker 1.

Original language	English
Pages (from-to)	2845-2848
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(98)00516-2
Publication status	Published - Oct 20 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00516-2

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AU - Kondo, Hirosato

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Y1 - 1998/10/20

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ER -

A stereoselective α-fucosylation reaction using 1-hydroxy 2,3,4-trio- benzyl-L-fucose donor for the practical synthesis of selectin blocker

Abstract

All Science Journal Classification (ASJC) codes

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