A simplified method of T1ρ mapping in clinical assessment of knee joint

Yukihisa Takayama, Masamitsu Hatakenaka, Takashi Yoshiura, Ken Okazaki, Kei Nishikawa, Tomoyuki Okuaki, Ivan Zimine, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: We assessed the clinical utility of our proposed simplified method for TT1ρ mapping calculations. Materials and Methods: Ten healthy subjects underwent scanning on a 3-tesla magnetic resonance system using an 8-channel phased-array coil. For each subject, we obtained sagittal T1ρ-prepared images using 5 different time of spin-lock pulses (TSL=1, 20, 40, 60, and 80 ms), produced conventional TT1ρ maps (cT1ρ maps) using all TSLs, and recomputed our proposed simplified T1ρ maps (sT1ρ maps) using a decreasing number of TSLs (from 4 to 2). We then investigated the differences and correlations in T1ρ values of the tissues obtained using different numbers of spin-lock times. Results: There was a strong positive correlation (single measure intraclass correlation coefficient=0.948; 95z confidence interval=0.911 to 0.970) in T1ρ values of tissues between the cT1ρ and sT1ρ [1, 80] maps. The 2 maps were comparable, though there was a small difference in T1ρ value between the two. The total scan time to acquire the data from 5 spin-lock times was 16 min 15 s. Similarity of the T1ρ [1, 80] map with the conventional approach reduced scan time by 60z, to 6min 30 s. Conclusion: The clinical relevance of our proposed simplified method is potentially similar to that of the conventional method, and our method requires a shorter examination time and generally preserves the reliability of the T1ρ relaxation time of the tissues.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalMagnetic Resonance in Medical Sciences
Issue number4
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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