A review on Tsukushi: mammalian development, disorders, and therapy

Arif Istiaq, Kunimasa Ohta

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJournal of Cell Communication and Signaling
Issue number4
Publication statusPublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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