A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Yoshiko Kagimoto, Hisakata Yamada, Takahiro Ishikawa, Naoyoshi Maeda, Fumi Goshima, Yukihiro Nishiyama, Masutaka Furue, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


IL-15 plays a critical role in the development and maturation of γδ intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-β1 upon TCR triggering than in control mice. In vivo neutralization of TGF-β ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-β1, promoting wound healing but impeding protection against genital HSV-2 infection.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of Leukocyte Biology
Issue number1
Publication statusPublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology


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