TY - JOUR
T1 - A receptor for green tea polyphenol EGCG
AU - Tachibana, Hirofumi
AU - Koga, Kiyoshi
AU - Fujimura, Yoshinori
AU - Yamada, Koji
N1 - Funding Information:
We thank T. Shimomura for helpful discussions. We thank M. Sumida and C. Tahara for technical assistance. This work was supported in part by grants from Bio-oriented Technology Research Advancement Institution and from Integrated Research on Safety and Physiological Function of Food, MAFF, Japan, to H.T.
PY - 2004/4
Y1 - 2004/4
N2 - The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar Kd value.
AB - The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar Kd value.
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U2 - 10.1038/nsmb743
DO - 10.1038/nsmb743
M3 - Article
C2 - 15024383
AN - SCOPUS:1842525199
SN - 1545-9993
VL - 11
SP - 380
EP - 381
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
IS - 4
ER -
