A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Rie Wakabayashi; Ryutaro Ishiyama; Noriho Kamiya; Masahiro Goto

doi:10.1039/c4md00179f

A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Rie Wakabayashi, Ryutaro Ishiyama, Noriho Kamiya, Masahiro Goto

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT). Using emulsification and freeze-drying processes in the presence of a hydrophilic surfactant, Pluronic F-68 or F-127, CPT-Pluronic complexes with crystalline features were synthesised. Investigation of the in vitro anticancer activities and cellular internalisation of the complexes revealed that the SCN efficiently delivered CPT to cells while maintaining anticancer activity.

Original language	English
Pages (from-to)	1515-1519
Number of pages	5
Journal	MedChemComm
Volume	5
Issue number	10
DOIs	https://doi.org/10.1039/c4md00179f
Publication status	Published - Oct 1 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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abstract = "In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT). Using emulsification and freeze-drying processes in the presence of a hydrophilic surfactant, Pluronic F-68 or F-127, CPT-Pluronic complexes with crystalline features were synthesised. Investigation of the in vitro anticancer activities and cellular internalisation of the complexes revealed that the SCN efficiently delivered CPT to cells while maintaining anticancer activity.",

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AU - Ishiyama, Ryutaro

AU - Kamiya, Noriho

AU - Goto, Masahiro

PY - 2014/10/1

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AB - In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT). Using emulsification and freeze-drying processes in the presence of a hydrophilic surfactant, Pluronic F-68 or F-127, CPT-Pluronic complexes with crystalline features were synthesised. Investigation of the in vitro anticancer activities and cellular internalisation of the complexes revealed that the SCN efficiently delivered CPT to cells while maintaining anticancer activity.

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A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Abstract

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