A novel neuropeptide, Hym-176, induces contraction of the ectodermal muscle in Hydra

Seungshic Yum, Toshio Takahashi, Osamu Koizumi, Yuki Ariura, Yoshitaka Kobayakawa, Shirou Mohri, Toshitaka Fujisawa

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61 Citations (Scopus)


During the course of a systematic non-targeting screening of peptide signal molecules in Hydra, we identified a novel myoactive neuropeptide called Hym-176. The primary structure of Hym-176 was determined to be APFIFPGPKV amide. It specifically and reversibly induced contraction of the ectodermal muscle of the hydra body column in vivo. However, it had no effect on the ectodermal muscle of the tentacles. The structure-activity relationship analysis showed that the sequence of FIFPGPKV amide is a minimal requirement for the myoactivity. Removal of an amide group from the C-terminus completely abolished the activity. By using the antibody specific to Hym-176, the tissue localization of the peptide in hydra was determined immunohistochemically. The intense immunoreactivity was found in the peduncle nerve cells, indicating that Hym-176 is a neuropeptide.

Original languageEnglish
Pages (from-to)584-590
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Jul 30 1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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