A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto; Kenji Kawamura; Daisuke Asai; Takeshi Mori; Takurou Niidome; Yoko Shoji; Hideki Nakashima; Yoshiki Katayama

A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto
, Kenji Kawamura
, Daisuke Asai
, Takeshi Mori
, Takurou Niidome
, Yoko Shoji
, Hideki Nakashima
, Yoshiki Katayama

Research output: Contribution to conference › Paper › peer-review

Abstract

We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

Original language	English
Pages	4867
Number of pages	1
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sept 20 2006 → Sept 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	9/20/06 → 9/22/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

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title = "A novel gene carrier for the therapy of viral infection disease",

abstract = "We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.",

author = "Masanori Kuramoto and Kenji Kawamura and Daisuke Asai and Takeshi Mori and Takurou Niidome and Yoko Shoji and Hideki Nakashima and Yoshiki Katayama",

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note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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T1 - A novel gene carrier for the therapy of viral infection disease

AU - Kuramoto, Masanori

AU - Kawamura, Kenji

AU - Asai, Daisuke

AU - Mori, Takeshi

AU - Niidome, Takurou

AU - Shoji, Yoko

AU - Nakashima, Hideki

AU - Katayama, Yoshiki

PY - 2006

Y1 - 2006

N2 - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

AB - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

UR - https://www.scopus.com/pages/publications/33846144803

UR - https://www.scopus.com/pages/publications/33846144803#tab=citedBy

M3 - Paper

AN - SCOPUS:33846144803

SP - 4867

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

A novel gene carrier for the therapy of viral infection disease

Abstract

Other

UN SDGs

All Science Journal Classification (ASJC) codes

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