A novel fiber-free technique for brain activity imaging in multiple freely behaving mice

Shigenori Inagaki, Masakazu Agetsuma, Takeharu Nagai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Brain functions and related psychiatric disorders have been investigated by recording electrophysiological field potential. When recording it, a conventional method requires fiber-based apparatus connected to the brain, which however hampers the simultaneous measurement in multiple animals (e.g. by a tangle of fibers). Here, we propose a fiber-free recording technique in conjunction with a ratiometric bioluminescent voltage indicator. Our method allows investigation of electrophysiological filed potential dynamics in multiple freely behaving animals simultaneously over a long time period. Therefore, this fiber-free technique opens up the way to investigate a new mechanism of brain function that governs social behaviors and animal-to-animal interaction.

Original languageEnglish
Title of host publicationOptogenetics and Optical Manipulation 2018
EditorsE. Duco Jansen, Samarendra K. Mohanty, Nitish V. Thakor, Nitish V. Thakor
ISBN (Electronic)9781510614499
Publication statusPublished - 2018
Externally publishedYes
EventOptogenetics and Optical Manipulation 2018 - San Francisco, United States
Duration: Jan 27 2018Jan 28 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptogenetics and Optical Manipulation 2018
Country/TerritoryUnited States
CitySan Francisco

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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