A novel CD3 J11d+ subset of CD4+CD8 cells repopulating thymus in radiation bone marrow chimeras

Koji Matsumoto, Yasunobu Yoshikai, Goro Matsuzaki, Taiji Asano, Kikuo Nomoto

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Sequential appearance of T cell subpopulations occurs in the thymus of irradiated AKR (H‐2k, Thy‐1.1) mice at an early stage after transplantation with bone marrow cells of C3H/HeN (H‐2k, Thy‐1.2) mice. The donor‐derived thymocytes were first detected on day 8 after bone marrow reconstitution. Although most of the thymocytes were CD4CD8 cells, an appreciable level of CD4+CD8+ cells was detected in the thymus at this stage. The early appearing CD4+CD8 cells were a novel subset of thymocytes that were J11d+CD3. From day 10 to day 21 the proportion of CD4+CD8CD3J11d+ cells decreased while the proportion of CD4+CD8 cells and CD4+CD8CD3+J11d cells increased. The CD4+CD8CD3 cells seem to diversify to form CD4+CD8+ thymocytes after short‐term culture in vitro. These results suggested the existence of a differential pathway from CD4CD8 cells to CD4+CD8+ cells via CD4+CD8 cells in the thymus.

Original languageEnglish
Pages (from-to)1203-1207
Number of pages5
JournalEuropean Journal of Immunology
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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