TY - JOUR
T1 - A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis
AU - Nishimori, Hiroyuki
AU - Shiratsuchi, Takayuki
AU - Urano, Tsutomu
AU - Kimura, Yasutoshi
AU - Kiyono, Kunihiko
AU - Tatsumi, Kunihiko
AU - Yoshida, Shigeo
AU - Ono, Mayumi
AU - Kuwano, Michihiko
AU - Nakamura, Yusuke
AU - Tokino, Takashi
N1 - Funding Information:
This work was partially supported by a research grant of the Princess Takamatsu Cancer Research Fund (96 – 22805) to T.T.
PY - 1997
Y1 - 1997
N2 - The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.
AB - The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.
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U2 - 10.1038/sj.onc.1201542
DO - 10.1038/sj.onc.1201542
M3 - Article
C2 - 9393972
AN - SCOPUS:9844261161
SN - 0950-9232
VL - 15
SP - 2145
EP - 2150
JO - Oncogene
JF - Oncogene
IS - 18
ER -
