A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement

Katsuhiko Tomooka; Takahiro Takeda; Au Wing Kuen; Takeshi Nakai

doi:10.3987/com-97-s(n)102

A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement

Katsuhiko Tomooka, Takahiro Takeda, Au Wing Kuen, Takeshi Nakai

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C3').

Original language	English
Pages (from-to)	671-674
Number of pages	4
Journal	Heterocycles
Volume	47
Issue number	2
DOIs	https://doi.org/10.3987/com-97-s(n)102
Publication status	Published - 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/com-97-s(n)102

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title = "A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement",

abstract = "An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C3').",

author = "Katsuhiko Tomooka and Takahiro Takeda and Kuen, {Au Wing} and Takeshi Nakai",

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AU - Tomooka, Katsuhiko

AU - Takeda, Takahiro

AU - Kuen, Au Wing

AU - Nakai, Takeshi

PY - 1998

Y1 - 1998

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AB - An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C3').

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A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement

Abstract

All Science Journal Classification (ASJC) codes

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