TY - JOUR
T1 - A new strategy for surgical intervention of bisphosphonate-related osteonecrosis of the jaw
T2 - A retrospective study
AU - Yamada, Shin Ichi
AU - Hayashida, Saki
AU - Yanamoto, Souichi
AU - Naruse, Tomofumi
AU - Matsusita, Yuki
AU - Uda, Akiko
AU - Rokutanda, Satoshi
AU - Kakehashi, Hiroe
AU - Ikeda, Hisazumi
AU - Asahina, Izumi
AU - Umeda, Masahiro
N1 - Publisher Copyright:
© 2016, Nagasaki University School of Medicine. All rights reserved.
PY - 2016/4
Y1 - 2016/4
N2 - Bisphosphonates (BPs) are now widely used to treat various skeletal complications. Although the number of reported cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is rapidly increasing worldwide, therapeutic strategies remain controversial. Conservative treatments including antibacterial mouth rinses, the systemic administration of antibiotics, and superficial debridement in stage II BRONJ have been recommended by the American Association of Oral and Maxillofacial Surgeons position paper. However, these treatments are only partially successful. We performed a surgical intervention that consisted of osteotomy and primary wound closure in patients with stages II and III BRONJ. Forty-three out of 44 cases were treated effectively by this strategy, leading to improvements in quality of life. All BRONJ patients treated with oral BPs were treated successfully by the surgical intervention. We also proposed a surgical intervention for patients with stage II BRONJ.
AB - Bisphosphonates (BPs) are now widely used to treat various skeletal complications. Although the number of reported cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is rapidly increasing worldwide, therapeutic strategies remain controversial. Conservative treatments including antibacterial mouth rinses, the systemic administration of antibiotics, and superficial debridement in stage II BRONJ have been recommended by the American Association of Oral and Maxillofacial Surgeons position paper. However, these treatments are only partially successful. We performed a surgical intervention that consisted of osteotomy and primary wound closure in patients with stages II and III BRONJ. Forty-three out of 44 cases were treated effectively by this strategy, leading to improvements in quality of life. All BRONJ patients treated with oral BPs were treated successfully by the surgical intervention. We also proposed a surgical intervention for patients with stage II BRONJ.
UR - http://www.scopus.com/inward/record.url?scp=84969973378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969973378&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84969973378
SN - 0001-6055
VL - 60
SP - 97
EP - 102
JO - Acta Medica Nagasakiensia
JF - Acta Medica Nagasakiensia
IS - 3
ER -