A new and convenient access to enantiopure C2-symmetric 2,5-diethynylpyrrolidine

Ikki Yonemura, Noriyuki Yasuda, Toshio Kawanami, Takeshi Hanamoto, Hiroshi Furuno, Junji Inanaga

    Research output: Contribution to journalArticlepeer-review


    Both (2R,5R)- and (2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via (R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation, chromatographic separation of the corresponding diastereomers, and cleavage of the benzylic C-N bond.

    Original languageEnglish
    Pages (from-to)433-436
    Number of pages4
    Issue number1
    Publication statusPublished - Jan 1 2006

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry


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