TY - JOUR
T1 - A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity
AU - Ashour, Ahmed
AU - Amen, Yhiya
AU - Nakagawa, Toshinori
AU - Niwa, Yasuharu
AU - Mira, Amira
AU - Ohnuki, Koichiro
AU - Murakami, Shinki
AU - Imao, Mitsuko
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
We acknowledge the help of CARICA CELAPI Co., Ltd. (Japan) for providing the material used for the study. The authors are much obliged to Ms. Noriko Yazawa for measurement of Bruker DRX 600 NMR spectrometer. We would like to thank Mr. Toshio Nishi, Evaluation Center of Materials Properties and Function, IMCE, Kyushu University for measurement of HR-FAB-MS. This work was partially supported by the Implementation of Projects to Nurture New Biotech Start-ups in Fukuoka Prefecture from Kurume Research Park Co., Ltd.
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/6/17
Y1 - 2020/6/17
N2 - An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Compounds 1 and 3 were reported for the first time from Papaya fruits through this study. The new compound showed a moderate antioxidant activity and a potent hair growth stimulating activity in vitro.
AB - An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Compounds 1 and 3 were reported for the first time from Papaya fruits through this study. The new compound showed a moderate antioxidant activity and a potent hair growth stimulating activity in vitro.
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U2 - 10.1080/14786419.2018.1530231
DO - 10.1080/14786419.2018.1530231
M3 - Article
C2 - 30513209
AN - SCOPUS:85058102844
SN - 1478-6419
VL - 34
SP - 1750
EP - 1755
JO - Natural Product Research
JF - Natural Product Research
IS - 12
ER -