A nano-sized gel-in-oil suspension for transcutaneous protein delivery

Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.

Original languageEnglish
Article number118495
JournalInternational Journal of Pharmaceutics
Publication statusPublished - Aug 15 2019

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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