TY - JOUR
T1 - A multiple primary carcinoma consisting of leukoplakia and SCC
T2 - A case report with p53 mutation analysis
AU - Hassan, Nur Mohammad Monsur
AU - Tada, Mitsuhiro
AU - Shindoh, Masanobu
AU - Hamada, Jun Ichi
AU - Kashiwazaki, Haruhiko
AU - Shimo, Tsuyoshi
AU - Ashikaga, Yuichi
AU - Yamazaki, Yutaka
AU - Sasaki, Akira
AU - Moriuchi, Tetsuya
AU - Inoue, Nobuo
PY - 2010/11
Y1 - 2010/11
N2 - Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of the three leukoplakias. One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). This case showed that individual oral tumours may have different genetic changes even when they develop in a single patient. Therefore, this report provided strong evidence that in cases of multiple tumours it is necessary to design tailor-made therapies for each individual tumour rather than a single standardised therapy for all multiple tumours.
AB - Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of the three leukoplakias. One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). This case showed that individual oral tumours may have different genetic changes even when they develop in a single patient. Therefore, this report provided strong evidence that in cases of multiple tumours it is necessary to design tailor-made therapies for each individual tumour rather than a single standardised therapy for all multiple tumours.
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UR - http://www.scopus.com/inward/citedby.url?scp=78650229518&partnerID=8YFLogxK
M3 - Article
C2 - 21115940
AN - SCOPUS:78650229518
SN - 0250-7005
VL - 30
SP - 4773
EP - 4778
JO - Anticancer research
JF - Anticancer research
IS - 11
ER -
