TY - JOUR
T1 - A metastable DWARF1 epigenetic mutant affecting plant stature in rice
AU - Miura, Kotaro
AU - Agetsuma, Masakazu
AU - Kitano, Hidemi
AU - Yoshimura, Atsushi
AU - Matsuoka, Makoto
AU - Jacobsen, Steven E.
AU - Ashikari, Motoyuki
PY - 2009/7/7
Y1 - 2009/7/7
N2 - Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA. We identified a spontaneous rice mutant, Epi-d1, that shows a metastable dwarf phenotype. The phenotype is mitotically and meiotically inheritable and corresponds to the metastable epigenetic silencing of the DWARF1 (D1) gene. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations. Compared with other known epigenetic silenced loci in plants such as paramutable maize alleles and silent Arabidopsis genes, the Epi-d1 silencing phenomenon shows a high level of bidirectional metastable mutability. Epigenetic alleles such as Epi-d1 could thus provide for rapid adaptation under selective conditions.
AB - Epigenetic mutations confer heritable changes in gene expression that are not due to changes in the underlying sequence of the DNA. We identified a spontaneous rice mutant, Epi-d1, that shows a metastable dwarf phenotype. The phenotype is mitotically and meiotically inheritable and corresponds to the metastable epigenetic silencing of the DWARF1 (D1) gene. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations. Compared with other known epigenetic silenced loci in plants such as paramutable maize alleles and silent Arabidopsis genes, the Epi-d1 silencing phenomenon shows a high level of bidirectional metastable mutability. Epigenetic alleles such as Epi-d1 could thus provide for rapid adaptation under selective conditions.
UR - http://www.scopus.com/inward/record.url?scp=67650494690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650494690&partnerID=8YFLogxK
U2 - 10.1073/pnas.0901942106
DO - 10.1073/pnas.0901942106
M3 - Article
C2 - 19541604
AN - SCOPUS:67650494690
SN - 0027-8424
VL - 106
SP - 11218
EP - 11223
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 27
ER -