A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

Tomohiro Iguchi; Ryutaro Uchi; Sho Nambara; Tomoko Saito; Hisateru Komatsu; Hidenari Hirata; Masami Ueda; Shotaro Sakimura; Yuki Takano; Jyunji Kurashige; Yoshiaki Shinden; Hidetoshi Eguchi; Keishi Sugimachi; Yoshihiko Maehara; Koshi Mimori

A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

Tomohiro Iguchi, Ryutaro Uchi, Sho Nambara, Tomoko Saito, Hisateru Komatsu, Hidenari Hirata, Masami Ueda, Shotaro Sakimura, Yuki Takano, Jyunji Kurashige, Yoshiaki Shinden, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

Research output: Contribution to journal › Article › peer-review

178 Citations (Scopus)

Abstract

Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

Original language	English
Pages (from-to)	1385-1388
Number of pages	4
Journal	Anticancer research
Volume	35
Issue number	3
Publication status	Published - Mar 1 2015

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{e4dcfe4f013648c680ad291f1ab62747,

title = "A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer",

abstract = "Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.",

author = "Tomohiro Iguchi and Ryutaro Uchi and Sho Nambara and Tomoko Saito and Hisateru Komatsu and Hidenari Hirata and Masami Ueda and Shotaro Sakimura and Yuki Takano and Jyunji Kurashige and Yoshiaki Shinden and Hidetoshi Eguchi and Keishi Sugimachi and Yoshihiko Maehara and Koshi Mimori",

year = "2015",

month = mar,

day = "1",

language = "English",

volume = "35",

pages = "1385--1388",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "3",

}

TY - JOUR

T1 - A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

AU - Iguchi, Tomohiro

AU - Uchi, Ryutaro

AU - Nambara, Sho

AU - Saito, Tomoko

AU - Komatsu, Hisateru

AU - Hirata, Hidenari

AU - Ueda, Masami

AU - Sakimura, Shotaro

AU - Takano, Yuki

AU - Kurashige, Jyunji

AU - Shinden, Yoshiaki

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Maehara, Yoshihiko

AU - Mimori, Koshi

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

AB - Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

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M3 - Article

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AN - SCOPUS:84924970601

SN - 0250-7005

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JO - Anticancer research

JF - Anticancer research

IS - 3

ER -

A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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