TY - JOUR
T1 - A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
AU - Suzuki, Harumitsu
AU - Nakamura, Yasuyuki
AU - Matsuo, Keitaro
AU - Imaeda, Nahomi
AU - Goto, Chiho
AU - Narita, Akira
AU - Shimizu, Atsushi
AU - Takashima, Naoyuki
AU - Matsui, Kenji
AU - Miura, Katsuyuki
AU - Nakatochi, Masahiro
AU - Hishida, Asahi
AU - Tamura, Takashi
AU - Kadomatsu, Yuka
AU - Okada, Rieko
AU - Nishida, Yuichiro
AU - Shimanoe, Chisato
AU - Nishimoto, Daisaku
AU - Takezaki, Toshiro
AU - Oze, Isao
AU - Ito, Hidemi
AU - Ikezaki, Hiroaki
AU - Murata, Masayuki
AU - Matsui, Daisuke
AU - Ozaki, Etsuko
AU - Mikami, Haruo
AU - Nakamura, Yohko
AU - Suzuki, Sadao
AU - Watanabe, Miki
AU - Arisawa, Kokichi
AU - Uemura, Hirokazu
AU - Kuriki, Kiyonori
AU - Momozawa, Yukihide
AU - Kubo, Michiaki
AU - Kita, Yoshikuni
AU - Takeuchi, Kenji
AU - Wakai, Kenji
N1 - Funding Information:
Funding This study was supported by a Grants-in-Aid for Scientific Research for Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001), and by JSPS KAKENHI Grants (No. 16H06277) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. This study was also supported in part by funding for the BioBank Japan Project from the Japan Agency for Medical Research and development from April 2015, and the Ministry of Education, Culture, Sports, Science and Technology from April 2003 to March 2015.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/6
Y1 - 2021/6
N2 - Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.
AB - Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.
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U2 - 10.1038/s41430-020-00823-z
DO - 10.1038/s41430-020-00823-z
M3 - Article
C2 - 33281188
AN - SCOPUS:85097206785
SN - 0954-3007
VL - 75
SP - 937
EP - 945
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 6
ER -
