TY - JOUR
T1 - A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative
T2 - In vitro evaluation of early-stage biliary sludge formation inhibition
AU - Toyokawa, Yoshihide
AU - Kobayashi, Shingo
AU - Tsuchiya, Haruka
AU - Shibuya, Tomokazu
AU - Aoki, Makiko
AU - Sumiya, Jun
AU - Ooyama, Shun
AU - Ishizawa, Tetsuya
AU - Makino, Naohiko
AU - Ueno, Yoshiyuki
AU - Tanaka, Masaru
N1 - Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors have financial conflicts of interest to disclose concerning the study. This study was supported by Research funding of Center of innovation program (COI) in Yamagata University (2014–2018), and by Yamagata University -Center of Excellence (YU-COE) research funding (2014–2016). This work was partially supported by JSPS KAKENHI (Grant Number: JP19H05720 ) and Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials .
Publisher Copyright:
© 2020
PY - 2021/1
Y1 - 2021/1
N2 - The adhesion and deformation behavior of proteins at the inner surface of fully covered, self-expandable metallic stents coated with biocompatible polymers, poly(2-methoxyethyl acrylate) (PMEA) and poly(3-methoxypropyl acrylate) (PMC3A), were analyzed. Model bile solution, proteins, and bacteria were used to unravel the inhibitory ability of the polymer coatings. Adsorbance of proteins and adherence of bacteria were both strongly inhibited by the polymer coatings. Circulation tests were performed under clinical conditions using human bile from patients. Adsorption/deformation of proteins and early-stage sludge formation were inhibited on stent surfaces coated with PMEA derivatives. The present study revealed that early-stage biliary sludge formation on PMEA- and PMC3A-coated stents was suppressed due to the strong resistance of the polymers to protein adsorption/deformation, brought about by intermediate water in hydrated polymer coatings, which is not present in conventional coating materials, such as silicone and polyurethane.
AB - The adhesion and deformation behavior of proteins at the inner surface of fully covered, self-expandable metallic stents coated with biocompatible polymers, poly(2-methoxyethyl acrylate) (PMEA) and poly(3-methoxypropyl acrylate) (PMC3A), were analyzed. Model bile solution, proteins, and bacteria were used to unravel the inhibitory ability of the polymer coatings. Adsorbance of proteins and adherence of bacteria were both strongly inhibited by the polymer coatings. Circulation tests were performed under clinical conditions using human bile from patients. Adsorption/deformation of proteins and early-stage sludge formation were inhibited on stent surfaces coated with PMEA derivatives. The present study revealed that early-stage biliary sludge formation on PMEA- and PMC3A-coated stents was suppressed due to the strong resistance of the polymers to protein adsorption/deformation, brought about by intermediate water in hydrated polymer coatings, which is not present in conventional coating materials, such as silicone and polyurethane.
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U2 - 10.1016/j.msec.2020.111386
DO - 10.1016/j.msec.2020.111386
M3 - Article
C2 - 33545807
AN - SCOPUS:85096175784
SN - 0928-4931
VL - 120
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 111386
ER -