TY - JOUR
T1 - A formal synthesis of aplysiatoxin
T2 - enantioselective synthesis of kishi's aldehyde
AU - Okamura, Hiroaki
AU - Kuroda, Satoru
AU - Ikegami, Satoru
AU - Tomita, Kenji
AU - Sugimoto, Yu ichi
AU - Sakaguchi, Shin ichi
AU - Ito, Yoshio
AU - Katsuki, Tsutomu
AU - Yamaguchi, Masaru
PY - 1993
Y1 - 1993
N2 - This paper describes the enantioselective synthesis of key fragments (12, 18, 24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2). Since 2 has already been transformed into 1a in a short step, its synthesis constitutes a formal total synthesis of 1a. Synthesis of fragments of aplysiatoxin (1a) and their convergent assembly to the key intermediate, Kishi's aldehyde (2), for the synthesis of 1a are described.
AB - This paper describes the enantioselective synthesis of key fragments (12, 18, 24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2). Since 2 has already been transformed into 1a in a short step, its synthesis constitutes a formal total synthesis of 1a. Synthesis of fragments of aplysiatoxin (1a) and their convergent assembly to the key intermediate, Kishi's aldehyde (2), for the synthesis of 1a are described.
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U2 - 10.1016/S0040-4020(01)81547-7
DO - 10.1016/S0040-4020(01)81547-7
M3 - Article
AN - SCOPUS:0027437390
SN - 0040-4020
VL - 49
SP - 10531
EP - 10554
JO - Tetrahedron
JF - Tetrahedron
IS - 46
ER -
