A fast Look-Locker method for T 1 mapping of the head and neck region

Toru Chikui, Kenji Tokumori, Ryosuke Zeze, Tomoko Shiraishi, Takahiro Ichihara, Masamitsu Hatakenaka, Kazunori Yoshiura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective: A sequence for T1 relaxation time measurements that allows a high-resolution image to be obtained within a short acquisition time is described. Its application to the orofacial region is investigated. Methods: The sequence is based on the Look-Locker (LL) method and employs a magnetization-preparation pulse prior to data acquisition, with either a turbo-field echo (TFE) or turbo-field echo echo-planar imaging (TFEPI) sequence. We applied the multiple LL sequence by synchronizing the data acquisition with the virtual electrocardiogram. T1 results from the LL sequence were compared with those from the inversion recovery (IR) sequence. In an in vitro study, we evaluated the T1 maps of contrast medium at different concentrations. In an in vivo study, we evaluated the T1 maps in seven volunteers. Results: In the in vitro study, the correlation between the T1 values obtained from the LL sequence and those from the IR sequence was high, with an R 2 of more than 0.99. For T1 values between 200 and 1,500 ms, the difference between the two methods was less than 7%. In the in vivo study, a high correlation was observed between the T1 values from the IR sequence and those from the LL sequence. The scan duration for the LL sequence was less than 3 min. Conclusion: Our method, based on the LL sequence, was found to be clinically useful for producing a T1 map.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalOral Radiology
Issue number1
Publication statusPublished - Jun 2009

All Science Journal Classification (ASJC) codes

  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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