A diet supplemented with cholic acid elevates blood pressure accompanied by albuminuria in rats

Tomoko Shimoda, Hidehisa Shimizu, Wakana Iwasaki, Hongxia Liu, Yoshie Kamo, Koji Tada, Taketo Hanai, Shota Hori, Ga Hyun Joe, Yasutake Tanaka, Masao Sato, Hitoshi Miyazaki, Satoshi Ishizuka

Research output: Contribution to journalArticlepeer-review

Abstract

A diet supplemented with cholic acid (CA), the primary 12α-hydroxylated bile acid, can induce hepatic lipid accumulation in rats without obesity. This study examined the effects of a CA-supplemented diet on blood pressure (BP). After acclimation, WKAH/HkmSlc rats (3 weeks old) were divided into two groups and fed with a control AIN-93-based diet or a CA-supplemented diet (0.5 g CA/kg) for 13 weeks. The CA diet increased systolic and diastolic BP as well as hepatic lipid concentrations in the rats. No changes were found in the blood sodium concentration. Urinary albumin concentration increased in CA-fed rats. An increase was observed in the hepatic expression of ATP-binding cassette subfamily B member 1B that correlated BPs and urinary albumin concentration accompanied by an increase in portal taurocholic acid concentration. These results suggest that 12α-hydroxylated bile acids are involved in increased BP and albuminuria via alteration of hepatic function.

Original languageEnglish
Pages (from-to)434-441
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume87
Issue number4
DOIs
Publication statusPublished - Apr 1 2023

All Science Journal Classification (ASJC) codes

  • General Medicine

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