A conservation law for virus infection kinetics in vitro

Yusuke Kakizoe, Satoru Morita, Shinji Nakaoka, Yasuhiro Takeuchi, Kei Sato, Tomoyuki Miura, Catherine A.A. Beauchemin, Shingo Iwami

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalJournal of Theoretical Biology
Publication statusPublished - Jul 7 2015

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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