TY - JOUR
T1 - A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q
T2 - Comparison with chromosome 21q
AU - Yamada, Yoichi
AU - Shirakawa, Tomoyo
AU - Taylor, Todd D.
AU - Okamura, Kohji
AU - Soejima, Hidenobu
AU - Uchiyama, Michiko
AU - Iwasaka, Tsuyoshi
AU - Mukai, Tsunehiro
AU - Muramoto, Ken Ichiro
AU - Sakaki, Yoshiyuki
AU - Ito, Takashi
N1 - Funding Information:
This work was in part supported by research grants from Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2006/8
Y1 - 2006/8
N2 - It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.
AB - It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.
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U2 - 10.1080/10425170600886128
DO - 10.1080/10425170600886128
M3 - Article
C2 - 17312950
AN - SCOPUS:33847217958
SN - 1042-5179
VL - 17
SP - 300
EP - 306
JO - DNA Sequence - Journal of DNA Sequencing and Mapping
JF - DNA Sequence - Journal of DNA Sequencing and Mapping
IS - 4
ER -