TY - JOUR
T1 - A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters
AU - Tanaka, A.
AU - Hisanaga, A.
AU - Inamasu, T.
AU - Hirata, M.
AU - Ishinishi, N.
N1 - Funding Information:
Acknowledgements--We are grateful to Professor M. Enjoji, Department of Pathology, Kyushu University, for direction and discussion, as well as Miss K. Miller for editorial assistance. This study was supported by a Foundation from the Fukuoka Cancer Society.
PY - 1988
Y1 - 1988
N2 - N-Nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA) were instilled intratracheally into male Syrian golden hamsters once a week for 15 wk. The total dosages were 1.5 mg and 7.5 mg of NDEA and 0.75 mg and 1.5 mg of NDMA. A control group simultaneously received phosphate buffer vehicle. Tumours related to instillation appeared principally in the respiratory tract and the liver. Over the entire lifespan of the animals tumour incidence rates in the respiratory tract were 100% in both the NDEA groups, 6% in both NDMA groups and 8% in the control group. The total incidences of liver tumours were 6% in the 0.75 mg NDMA group, 19% in the 1.5 mg NDMA group, zero in the NDEA groups, and 4% in the control group. These results indicate that, when administered by this route, NDEA is a much more potent carcinogen in the respiratory tract than is NDMA but NDMA alone seems to be carcinogenic to the liver, at a total dosage of 1.5 mg.
AB - N-Nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA) were instilled intratracheally into male Syrian golden hamsters once a week for 15 wk. The total dosages were 1.5 mg and 7.5 mg of NDEA and 0.75 mg and 1.5 mg of NDMA. A control group simultaneously received phosphate buffer vehicle. Tumours related to instillation appeared principally in the respiratory tract and the liver. Over the entire lifespan of the animals tumour incidence rates in the respiratory tract were 100% in both the NDEA groups, 6% in both NDMA groups and 8% in the control group. The total incidences of liver tumours were 6% in the 0.75 mg NDMA group, 19% in the 1.5 mg NDMA group, zero in the NDEA groups, and 4% in the control group. These results indicate that, when administered by this route, NDEA is a much more potent carcinogen in the respiratory tract than is NDMA but NDMA alone seems to be carcinogenic to the liver, at a total dosage of 1.5 mg.
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U2 - 10.1016/0278-6915(88)90025-7
DO - 10.1016/0278-6915(88)90025-7
M3 - Article
C2 - 3220327
AN - SCOPUS:0024242322
SN - 0278-6915
VL - 26
SP - 847
EP - 850
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 10
ER -