TY - JOUR
T1 - A comparative biomechanical study of bone ingrowth in two porous hydroxyapatite bioceramics
AU - Ren, Li Mei
AU - Todo, Mitsugu
AU - Arahira, Takaaki
AU - Yoshikawa, Hideki
AU - Myoui, Akira
N1 - Funding Information:
This work was supported in part by The Grant-in-Aid for Highly Functional Interface Science: Innovation of Biomaterials with Highly Functional Interface to Host and Parasite from the Ministry of Education, Science, Sports, and Culture of Japan .
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Calcium phosphate-based bioceramics have been widely used as artificial bone substitute materials because of their superior biocompatibility and osteoconductivity. In the present study, mechanical properties changes of two hydroxyapatite (HA) ceramics induced by bone ingrowth were tested and evaluated in a rabbit model. Both materials (NEOBONE ® , Apaceram-AX ® ) have highly interconnected pores with a porosity of 75-85%. The major structural difference between them lies in that Apaceram-AX ® has micropores smaller than 10 micrometers in diameter, whereas NEOBONE ® does not contain such micropores. Both materials were implanted into the femoral condyles of rabbits for the specified observation period (1, 5, 12, 24, and 48 weeks) and then evaluated by experimental approach in combination with finite element method (FEM). Results indicate that two porous bioceramics exhibit different degradability in vivo, and remarkably different variation of total stiffness, elastic modulus distribution, as well as strain energy density distribution calculated by FE simulation. These results demonstrate how the internal microstructures affect the progress of bone regeneration and mechanical properties with the duration of implantation, emphasizing the importance of biomaterial design tailored to various clinic applications. Additionally, this study showed a potential for applying the computational method to monitor the time-dependent biomechanical changes of implanted porous bioceramics.
AB - Calcium phosphate-based bioceramics have been widely used as artificial bone substitute materials because of their superior biocompatibility and osteoconductivity. In the present study, mechanical properties changes of two hydroxyapatite (HA) ceramics induced by bone ingrowth were tested and evaluated in a rabbit model. Both materials (NEOBONE ® , Apaceram-AX ® ) have highly interconnected pores with a porosity of 75-85%. The major structural difference between them lies in that Apaceram-AX ® has micropores smaller than 10 micrometers in diameter, whereas NEOBONE ® does not contain such micropores. Both materials were implanted into the femoral condyles of rabbits for the specified observation period (1, 5, 12, 24, and 48 weeks) and then evaluated by experimental approach in combination with finite element method (FEM). Results indicate that two porous bioceramics exhibit different degradability in vivo, and remarkably different variation of total stiffness, elastic modulus distribution, as well as strain energy density distribution calculated by FE simulation. These results demonstrate how the internal microstructures affect the progress of bone regeneration and mechanical properties with the duration of implantation, emphasizing the importance of biomaterial design tailored to various clinic applications. Additionally, this study showed a potential for applying the computational method to monitor the time-dependent biomechanical changes of implanted porous bioceramics.
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U2 - 10.1016/j.apsusc.2012.02.060
DO - 10.1016/j.apsusc.2012.02.060
M3 - Article
AN - SCOPUS:84869019947
SN - 0169-4332
VL - 262
SP - 81
EP - 88
JO - Applied Surface Science
JF - Applied Surface Science
ER -