[A case report of malignant lymphoma receiving infliximab therapy with Behçet's disease].

Koh Hei Sonoda, Takako Fukuhara, Horoshi Yoshikawa, Atsunobu Takeda, Takeru Yoshimura, Mitsuteru Akahoshi, Hirotake Kusumoto, Kentaro Kohno, Koji Kato, Koichi Akashi, Kenichi Kouhashi, Shinichi Aijima, Kenichi Namba, Tatsuro Ishibashi

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4 Citations (Scopus)


To report a case of malignant lymphoma occurring in Behçet's disease (BD) with infliximab therapy. A 62-year-old man was diagnosed with BD in 1997. Despite treatment with colchicine, cyclosporine and prednisolone, he had frequent bilateral posterior ocular attacks. He was started on infliximab in August 2007 and for 6 months had no ocular attacks. Cyclosporine was therefore reduced. After 4 years of infliximab administration, he had neither ocular attacks nor general symptoms. However, he had general malaise and weight loss from the end of March 2012. Peripheral blood examination showed abnormal cells, so we terminated the infliximab. Bone marrow aspiration showed diffuse proliferation of medium to large lymphoid cells, and the histological diagnosis was diffuse large B-cell lymphoma. He was treated with 8 cycles of chemotherapy and 4 times intrathecal chemotherapy, and is now in remission. After termination of infliximab, he had no further ocular attacks. Although malignant lymphoma associated with BD is rare, attending ophthalmologists need to keep it in mind.

Original languageEnglish
Pages (from-to)440-445
Number of pages6
JournalNippon Ganka Gakkai zasshi
Issue number5
Publication statusPublished - May 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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