A case of uterine metastasis of primary cutaneous malignant melanoma

Kayo Harada, Tomoko Maekawa, Yumiko Kaku, Masanobu Ogawa, Syuhei Imayama, Kazunori Urabe

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A 62-year-old female who had noticed a tumor at the back of her head in 2005 visited our hospital after resection at the climic in June 2006 under a diagnosis of malignant melanoma (T4bN0M0, stage II C), which was treated by expanding resection in July 2006. She was treated with DAV-feron chemotherapy three times. During follow-up, in July 2011, laboratory result showed increased 5-S-cysteinyldopa (31.5nmol /1), and an abnormal uptake of PET-CT was shown in the left deep cervical lymph node and in a part of an enlarged uterus. She was observed in the Gynecology Department of our hospital for multiple uterine myomas from July 2010, but magnetic resonance imaging revealed a new solid lesion in the left side of her uterus and enlarged uterine myomas after menopause. The patient underwent a total hysterectomy plus bilateral salpingo-oophorectomy in September 2011. Solid blackish masses were noticed in the myoma, and the final diagnosis was metastasis of malignant melanoma involving a uterine myoma. After she was treated with CDV chemotherapy for a total of three times after surgery, the serum level of 5-S-cysteinyldopa became normal, and the abnormal uptake of PET-CT disappeared completely at both neck and uterus. Although she did not have subjective or objective symptoms such as atypical genital bleeding, metastasis was revealed by increased 5-S-cysteinyldopa levels and diagnostic imaging, and she was successfully treated. In patients with melanoma it is important to pay attention to subjective symptoms and never miss signs of metastasis.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalNishinihon Journal of Dermatology
Issue number2
Publication statusPublished - 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology


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