A 66-year-old male, with a history of treated hepatitis C, was admitted to our hospital for liver tumors. He had undergone interferon treatment 11 years ago with sustained virological response since then. The radiological work-ups revealed that the main tumor with a satellite lesion was located in the anterior segment, with a typical enhancement pattern for hepatocellular carcinoma. All the hepatitis viral markers except anti-HBc and anti-HCV were negative. HCV RNA was also negative. A right lobectomy of the liver was undertaken with uncomplicated post-surgical course. We herein report an interesting case of hepatocellular carcinoma that occurred 11 years after achieving sustained virological response to interferon treatment.
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