A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine.

Yoshiro Horai; Atsuko Koyama; Tomoya Miyamura; Akie Hirata; Masataka Nakamura; Hitoshi Ando; Soichiro Takahama; Rumi Minami; Masahiro Yamamoto; Eiichi Suematsu

A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine.

Yoshiro Horai, Atsuko Koyama, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Soichiro Takahama, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

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1 Citation (Scopus)

Abstract

We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.

Original language	English
Pages (from-to)	24-28
Number of pages	5
Journal	Fukuoka igaku zasshi = Hukuoka acta medica
Volume	103
Issue number	1
Publication status	Published - Jan 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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abstract = "We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.",

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AU - Horai, Yoshiro

AU - Koyama, Atsuko

AU - Miyamura, Tomoya

AU - Hirata, Akie

AU - Nakamura, Masataka

AU - Ando, Hitoshi

AU - Takahama, Soichiro

AU - Minami, Rumi

AU - Yamamoto, Masahiro

AU - Suematsu, Eiichi

PY - 2012/1

Y1 - 2012/1

N2 - We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.

AB - We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.

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A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine.

Abstract

All Science Journal Classification (ASJC) codes

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