A 56-year-old man presented with a 10-month history of multiple progressive nodules on the face. These multiple exudative nodules were resistant to antibiotics, and erythematous indurated plaques developed on the neck and chest. According to the clinical course and histopathological examination, a diagnosis of pyoderma vegetans was made. Direct immunofluorescence test using IgG, IgA, IgM, C3 was negative. Administration of oral prednisolone, 30 mg/day, immediately resulted in a reduction in the size of the skin lesions.
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