TY - JOUR
T1 - A case of pyoderma gangrenosum in a patient with rheumatoid arthritis treated with abatacept
AU - Ikeda, Maki Akahoshi
AU - Yoshizawa, Seiji
AU - Motoshita, Junichi
AU - Furue, Masutaka
AU - Takeuchi, Satoshi
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/9
Y1 - 2016/9
N2 - Pyoderma gangrenosum (PG) is a neutrophilic dermatosis induced by trauma or infection, which frequently appears on the lower legs. Various autoimmune diseases and systemic tumour necrosis factor (TNF)-α-blocking treatment cause PG, suggesting that T-cell-mediated reactions are involved in the aetiology. We report here for the first time a case of PG occurring during treatment with abatacept, a T-cell co-stimulation blocker. In addition, we discuss a possible underlying disease mechanism.
AB - Pyoderma gangrenosum (PG) is a neutrophilic dermatosis induced by trauma or infection, which frequently appears on the lower legs. Various autoimmune diseases and systemic tumour necrosis factor (TNF)-α-blocking treatment cause PG, suggesting that T-cell-mediated reactions are involved in the aetiology. We report here for the first time a case of PG occurring during treatment with abatacept, a T-cell co-stimulation blocker. In addition, we discuss a possible underlying disease mechanism.
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U2 - 10.2340/00015555-2380
DO - 10.2340/00015555-2380
M3 - Article
C2 - 26912455
AN - SCOPUS:84983085484
SN - 0001-5555
VL - 96
SP - 822
EP - 823
JO - Acta dermato-venereologica
JF - Acta dermato-venereologica
IS - 6
ER -