TY - JOUR
T1 - A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
AU - Ohta, Miho
AU - Moriyama, Masafumi
AU - Goto, Yuichi
AU - Kawano, Shintaro
AU - Tanaka, Akihiko
AU - Maehara, Takashi
AU - Furukawa, Sachiko
AU - Hayashida, Jun Nosuke
AU - Kiyoshima, Tamotsu
AU - Shimizu, Mayumi
AU - Arinobu, Yojiro
AU - Nakamura, Seiji
N1 - Funding Information:
This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26293430, 26670869), the ‘Research on Measures for Intractable Diseases’ project, a matching fund subsidy from the Ministry of Health Labour and Welfare, Japan (H26-026, H26-050, H26-064, H26-083) and the ‘Takeda Science Foundation’.
Publisher Copyright:
© 2015 Ohta et al.
PY - 2015/2/21
Y1 - 2015/2/21
N2 - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
AB - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
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U2 - 10.1186/s12957-015-0459-z
DO - 10.1186/s12957-015-0459-z
M3 - Article
C2 - 25889621
AN - SCOPUS:84928735379
SN - 1477-7819
VL - 13
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
IS - 1
M1 - 67
ER -
