A case of MALT lymphoma with gammaglobulinemia and systemic lymph node swelling

Ruriko Kohno, Hiroshi Yoshikawa, Ri Ichiro Kohno, Kimiko Ishida, Toshinori Murata, Yoh Ichi Kawano, Tatsuro Ishibashi, Kennosuke Karube, Kazuya Shimoda

Research output: Contribution to journalArticlepeer-review


A 59-year-old male presented with impaired visual acuity in both eyes. He had been diagnosed with bilateral orbital lymphoid hyperplasia 23 years before. He had received radiation to his left orbit 16 years before. Biopsy of right orbital tumor 4 years before had led to the diagnosis of mucosa-associated lymphoid tissue (MALT) lymphoma, followed by radiation and systemic chemotherapy. His corrected visual acuity was 0.1 right and 0.5 left. He showed progression of orbital tumor, systemic lymphnode swelling and gammaglobulinemia. He had also gastric tumor, which was diagnosed as MALT lymphoma. Biopsy of cervical lymphnode showed no clonality of Ig gene. Systemic chemotherapy led to partial regression of lymphoma and to decreased serum level of immunoglobulin. MALT lymphoma in the present case appeared to be of orbital origin.

Original languageEnglish
Pages (from-to)1855-1860
Number of pages6
JournalJapanese Journal of Clinical Ophthalmology
Issue number12
Publication statusPublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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