TY - JOUR
T1 - A case of liver injury caused by Kyoukousou and Shin-Kyokubi, chinese dietary supplements for weight loss
AU - Dohmen, Kazufumi
AU - Tanaka, Hirofumi
AU - Shimoda, Shinji
AU - Aishima, Shinichi
N1 - Publisher Copyright:
© 2018 The Japan Society of Hepatology.
PY - 2018
Y1 - 2018
N2 - A 37-year-old woman with complaints of anorexia and general fatigue was admitted because of liver dysfunction. She had taken Shin-Kyokubi, a Chinese dietary supplement, for 1 month. Her laboratory data showed total bilirubin of 1.98 mg/dL, aspartate aminotransferase 1847 IU/L, alanine aminotransferase 991 IU/L and PT activity, 62.8%. Enhanced CT revealed inhomogeneous enhancement in the liver parenchyma. Her liver injury normalized after the discontinuation of Shin-Kyokubi. Pathological findings were compatible with the improvement of the drug-induced liver injury．She had a similar history of liver injury induced by another Chinese dietary supplement, Kyoukousou, at the age of 31 years. Both Chinese dietary supplements were confirmed to contain a governmentally non-approved substrate, sibutramine. As it is convenient for everyone to access the dietary supplements through the Internet, The present case must serve as a warning to physicians to be careful of the possibility of unexpected liver injury caused by Chinese dietary supplements.
AB - A 37-year-old woman with complaints of anorexia and general fatigue was admitted because of liver dysfunction. She had taken Shin-Kyokubi, a Chinese dietary supplement, for 1 month. Her laboratory data showed total bilirubin of 1.98 mg/dL, aspartate aminotransferase 1847 IU/L, alanine aminotransferase 991 IU/L and PT activity, 62.8%. Enhanced CT revealed inhomogeneous enhancement in the liver parenchyma. Her liver injury normalized after the discontinuation of Shin-Kyokubi. Pathological findings were compatible with the improvement of the drug-induced liver injury．She had a similar history of liver injury induced by another Chinese dietary supplement, Kyoukousou, at the age of 31 years. Both Chinese dietary supplements were confirmed to contain a governmentally non-approved substrate, sibutramine. As it is convenient for everyone to access the dietary supplements through the Internet, The present case must serve as a warning to physicians to be careful of the possibility of unexpected liver injury caused by Chinese dietary supplements.
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U2 - 10.2957/kanzo.59.171
DO - 10.2957/kanzo.59.171
M3 - Article
AN - SCOPUS:85044735103
SN - 0451-4203
VL - 59
SP - 171
EP - 179
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
IS - 3
ER -