A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component

Akira Maekawa; Kenichi Kohashi; Yuichi Yamada; Akira Nakamizo; Koji Yoshimoto; Masahiro Mizoguchi; Toru Iwaki; Yoshinao Oda

doi:10.1111/neup.12181

A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component

Akira Maekawa, Kenichi Kohashi, Yuichi Yamada, Akira Nakamizo, Koji Yoshimoto, Masahiro Mizoguchi, Toru Iwaki, Yoshinao Oda

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.

Original language	English
Pages (from-to)	260-265
Number of pages	6
Journal	Neuropathology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1111/neup.12181
Publication status	Published - Jun 1 2015

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Clinical Neurology

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10.1111/neup.12181

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title = "A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component",

abstract = "We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.",

author = "Akira Maekawa and Kenichi Kohashi and Yuichi Yamada and Akira Nakamizo and Koji Yoshimoto and Masahiro Mizoguchi and Toru Iwaki and Yoshinao Oda",

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AU - Maekawa, Akira

AU - Kohashi, Kenichi

AU - Yamada, Yuichi

AU - Nakamizo, Akira

AU - Yoshimoto, Koji

AU - Mizoguchi, Masahiro

AU - Iwaki, Toru

AU - Oda, Yoshinao

PY - 2015/6/1

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N2 - We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.

AB - We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.

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A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component

Abstract

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