A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Hironori Mikumo; Naoki Hamada; Eiji Harada; Toyoshi Yanagihara; Saiko Ogata; Hidetake Yabuuchi; Kayo Ijichi; Koichi Takayama; Yoichi Nakanishi

doi:10.1016/j.rmcr.2017.03.023

A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Hironori Mikumo, Naoki Hamada, Eiji Harada, Toyoshi Yanagihara, Saiko Ogata, Hidetake Yabuuchi, Kayo Ijichi, Koichi Takayama, Yoichi Nakanishi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S⁶ biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Respiratory Medicine Case Reports
Volume	21
DOIs	https://doi.org/10.1016/j.rmcr.2017.03.023
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

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10.1016/j.rmcr.2017.03.023

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title = "A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report",

abstract = "A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.",

author = "Hironori Mikumo and Naoki Hamada and Eiji Harada and Toyoshi Yanagihara and Saiko Ogata and Hidetake Yabuuchi and Kayo Ijichi and Koichi Takayama and Yoichi Nakanishi",

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language = "English",

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T1 - A case of immunoglobulin G4-related respiratory disease with multiple lung cysts

T2 - A case report

AU - Mikumo, Hironori

AU - Hamada, Naoki

AU - Harada, Eiji

AU - Yanagihara, Toyoshi

AU - Ogata, Saiko

AU - Yabuuchi, Hidetake

AU - Ijichi, Kayo

AU - Takayama, Koichi

AU - Nakanishi, Yoichi

PY - 2017

Y1 - 2017

N2 - A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.

AB - A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.

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JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

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A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

Abstract

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