TY - JOUR
T1 - A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus
AU - Fujihira, Mika
AU - Higashi, Taiki
AU - Yokomizo, Maiko
AU - Takase, Keiichirou
AU - Idewaki, Yasuhiro
AU - Fukunaga, Atsushi
AU - Sakurai, Kunitoshi
AU - Toyoshima, Hiroshi
AU - Ohtani, Hiroshi
AU - Nakamura, Udai
AU - Kitazono, Takanari
AU - Iwase, Masanori
N1 - Publisher Copyright:
© 2019 Japan Diabetes Society. All rights reserved.
PY - 2019
Y1 - 2019
N2 - An 80-year-old woman was admitted due to liver dysfunction. She had been treated for type 2 diabetes mellitus by oral anti-diabetic medications. Laboratory examinations findings were as follows: AST 96 IU/L, ALT 134 IU/L, γ -GTP 823 IU/L, fasting serum glucose 204 mg/dL, HbA1c 8.3 %, C-peptide 2.46 ng/mL, anti-GAD antibody 55.8 U/mL, and IgG4 704 mg/dL. Imaging showed marked dilation of bile ducts without swelling of the pancreas or narrowing of the pancreatic ducts. The histological findings of a liver biopsy were compatible with IgG4-related sclerosing cholangitis. Both steroid therapy and insulin therapy were started and led to the amelioration of the liver function and insulin secretion as well as a reduction in anti-GAD antibody. We herein report a case of IgG4-related sclerosing cholangitis associated with diabetes mellitus with positivity for anti-GAD antibody, a situation that is rare to our knowledge.
AB - An 80-year-old woman was admitted due to liver dysfunction. She had been treated for type 2 diabetes mellitus by oral anti-diabetic medications. Laboratory examinations findings were as follows: AST 96 IU/L, ALT 134 IU/L, γ -GTP 823 IU/L, fasting serum glucose 204 mg/dL, HbA1c 8.3 %, C-peptide 2.46 ng/mL, anti-GAD antibody 55.8 U/mL, and IgG4 704 mg/dL. Imaging showed marked dilation of bile ducts without swelling of the pancreas or narrowing of the pancreatic ducts. The histological findings of a liver biopsy were compatible with IgG4-related sclerosing cholangitis. Both steroid therapy and insulin therapy were started and led to the amelioration of the liver function and insulin secretion as well as a reduction in anti-GAD antibody. We herein report a case of IgG4-related sclerosing cholangitis associated with diabetes mellitus with positivity for anti-GAD antibody, a situation that is rare to our knowledge.
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U2 - 10.11213/tonyobyo.62.17
DO - 10.11213/tonyobyo.62.17
M3 - Article
AN - SCOPUS:85061510529
SN - 0021-437X
VL - 62
SP - 17
EP - 23
JO - Journal of the Japan Diabetes Society
JF - Journal of the Japan Diabetes Society
IS - 1
ER -
