A case of high-dose rate interstitial brachytherapy for locally recurrent rectal cancer

Shingo Noura, Masayuki Ohue, Kohei Murata, Masao Kameyama, Kentaro Kishi, K. Takachi, Hidetoshi Eguchi, Terumasa Yamada, Isao Miyashiro, Masahiko Yano, Hiroaki Ohigashi, Y. Sasaki, Osamu Ishikawa, Shingi Imaoka

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2 Citations (Scopus)


The patient was a 55-year-old female who underwent an abdomino-perineal resection for advanced lower rectal cancer. The tumor was a well differentiated adenocarcinoma, type 2 in the Japanese classification of colorectal carcinoma, and was measured 2.3 cm in size. Histologically, the tumor was considered to be stage IIIb (mp, n3(+), P0, H0, M(-)). She received adjuvant chemotherapy with 5'-DFUR. After 13 months from the surgery, the patient developed a hip pain. After 16 months from the surgery, a pelvic MRI scan revealed a 3 cm tumor in the perineum. Biopsy from the tumor revealed adenocarcinoma. Consequently, we diagnosed local recurrence in the perineum. Chemotherapy with CPT-11 (230 mg/body) and 5'-DFUR (800 mg/body) was administered for 2 cycles. Because the tumor was enlarged, high-dose rate interstitial brachytherapy was given to the recurrent site at a total dose of 54 Gy/9 fractions/5 days. There were no severe complications. CEA was decreased within normal range from a maximum of 9.3. No progress was detected on CT and MRI, and the hip pain had disappeared. The tumor marker is within normal range for about 2 years and QOL was improved. Hence, high dose rate interstitial brachytherapy appears to be effective for locally recurrent rectal cancer.

Original languageEnglish
Pages (from-to)1801-1803
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number12
Publication statusPublished - Nov 2006

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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