A case of gastric hyperplastic polyp with malignant transformation

Kotaro Shibahara, Yukiaki Haraguchi, Isamu Sasaki, Hideyasu Kiyonari, Tatuhiro Oishi, Akinori Iwashita, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In this paper we report a case of hyperplastic polyp with malignant transformation. The patient was followed up by annual radiographic and endoscopic examination during 9 years. The first gastroscopy revealed a semi-pedunculated polyp beneath the esophageal-cardiac junction, 1.5cm in diameter and slightly reddish with smooth surface. Histological findings showed a hyperplastic polyp. There was slight change in size, but no change in histological examination of the lesion during the follow-up. In 1996, the biopsy specimen showed an atypical epithelium and the polyp was removed by snear polypectomy. A microscopic examination revealed a well-differentiated adenocarcinoma. Immunohistochemically, p53 and Ki-67 immunostaining showed positive in the carcinoma portion of the adenocarcinoma bearing a hyperplastic polyp in the stomach.

Original languageEnglish
Pages (from-to)319-321
Number of pages3
Issue number61
Publication statusPublished - Jan 2005

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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