TY - JOUR
T1 - A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains
AU - Kimura, Naoki
AU - Ueno, Masaya
AU - Nakashima, Kinich
AU - Taga, Tetsuya
PY - 1999
Y1 - 1999
N2 - LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.
AB - LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.
UR - http://www.scopus.com/inward/record.url?scp=0032868234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032868234&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.jbchem.a022420
DO - 10.1093/oxfordjournals.jbchem.a022420
M3 - Article
C2 - 10393337
AN - SCOPUS:0032868234
SN - 0021-924X
VL - 126
SP - 180
EP - 187
JO - Journal of biochemistry
JF - Journal of biochemistry
IS - 1
ER -