A β-hairpin peptide with pH-controlled affinity for tumor cells

Shin Nosuke Nishimura, Kei Nishida, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalChemical Communications
Issue number4
Publication statusPublished - Jan 14 2022

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis


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