5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Jie Liu; Kenji Kurashiki; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1248/bpb.29.392

5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

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Abstract

5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC₅₀ of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

Original language	English
Pages (from-to)	392-395
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	2
DOIs	https://doi.org/10.1248/bpb.29.392
Publication status	Published - Feb 2006

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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abstract = "5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC50 of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.",

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AU - Kurashiki, Kenji

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AU - Kondo, Ryuichiro

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5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Abstract

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