TY - JOUR
T1 - 5α-Reductase inhibitory component from leaves of Artocarpus altilis
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
AU - Sakai, Kokki
AU - Buabarn, Supanida
AU - Dilokkunanant, Uraiwan
N1 - Funding Information:
Acknowledgments We are grateful to Prof. Y. Fnjimoto (College of Pharmacy. Nihon University, Japan) for providing us their NMR data. This work was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education (Research Fellowships of the Japan Society for the Promotion of Science for Young Scientist) and the Cosmetology Research Foundation (Tokyo, Japanlo
PY - 2000
Y1 - 2000
N2 - The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves of Artocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves of A. altilis. This compound showed more potent inhibitory effect (IC50 = 38 μM) than α-linolenic acid known as a naturally occurring potent inhibitor.
AB - The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves of Artocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves of A. altilis. This compound showed more potent inhibitory effect (IC50 = 38 μM) than α-linolenic acid known as a naturally occurring potent inhibitor.
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U2 - 10.1007/BF00776401
DO - 10.1007/BF00776401
M3 - Article
AN - SCOPUS:0142040201
SN - 1435-0211
VL - 46
SP - 385
EP - 389
JO - Journal of Wood Science
JF - Journal of Wood Science
IS - 5
ER -