TY - JOUR
T1 - 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus
AU - Arung, Enos Tangke
AU - Shimizu, Kuniyoshi
AU - Tanaka, Hiroyuki
AU - Kondo, Ryuichiro
N1 - Funding Information:
We thank the Japan Society for Promotion of Science (JSPS) for the support of this research.
PY - 2010/9
Y1 - 2010/9
N2 - In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC 50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 μM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC 50 of 1 was 56.7 μM with less cytotoxicity.
AB - In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC 50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 μM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC 50 of 1 was 56.7 μM with less cytotoxicity.
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U2 - 10.1016/j.fitote.2010.03.011
DO - 10.1016/j.fitote.2010.03.011
M3 - Article
C2 - 20230878
AN - SCOPUS:77955709280
SN - 0367-326X
VL - 81
SP - 640
EP - 643
JO - Fitoterapia
JF - Fitoterapia
IS - 6
ER -