3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats

K. Mizokami; K. Inoue; M. Sunouchi; K. Fujimori; A. Takanaka; Y. Omori

doi:10.1016/0006-291X(82)91661-8

3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats

K. Mizokami, K. Inoue, M. Sunouchi, K. Fujimori, A. Takanaka, Y. Omori

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. The inductions of the AM- and the HB-metabolizing enzymes in fetal liver microsomes of rat by the maternal administration of 3-MC occurred exclusively in fetal period and simultaneously hemoprotein like phenobarbital-induced type P-450 different from that in maternal liver microsomes was newly induced in fetal liver microsomes of rats.

Original language	English
Pages (from-to)	6-11
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(82)91661-8
Publication status	Published - Jul 16 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(82)91661-8

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3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats. / Mizokami, K.; Inoue, K.; Sunouchi, M. et al.
In: Biochemical and Biophysical Research Communications, Vol. 107, No. 1, 16.07.1982, p. 6-11.

Research output: Contribution to journal › Article › peer-review

Mizokami, K, Inoue, K, Sunouchi, M, Fujimori, K, Takanaka, A & Omori, Y 1982, '3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats', Biochemical and Biophysical Research Communications, vol. 107, no. 1, pp. 6-11. https://doi.org/10.1016/0006-291X(82)91661-8

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abstract = "The characteristic nature of the drug-metabolizing system in fetal liver microsomes of rats was investigated. The aminopyrine(AM)- and the hexobarbital (HB)-metabolizing activities in fetal liver microsomes of the 21st day of pregnancy were induced by the maternal administration of 3-methylcholanthrene (3-MC) once daily on the 18th and the 19th day of pregnancy, while they were inhibited in maternal liver microsomes. The inductions of the AM- and the HB-metabolizing enzymes in fetal liver microsomes of rat by the maternal administration of 3-MC occurred exclusively in fetal period and simultaneously hemoprotein like phenobarbital-induced type P-450 different from that in maternal liver microsomes was newly induced in fetal liver microsomes of rats.",

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AU - Sunouchi, M.

AU - Fujimori, K.

AU - Takanaka, A.

AU - Omori, Y.

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3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats

Abstract

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