2,3,7,8-Tetrachlorodibenzo-p-dioxin/Polychlorinated Biphenyls

Yukiko Ogino, Shinichi Miyagawa, Taisen Iguchi

Research output: Chapter in Book/Report/Conference proceedingChapter


TCDDs are formed as unintentional byproducts during the manufacture of chemicals and pesticides, bleaching of pulp and paper, and incineration of industrial and municipal waste. PCBs were produced commercially and used extensively as coolants and lubricants in transformers and other industrial equipment until their production and use were banned. These chemicals are still found in the environment and accumulate in the food chain, and can thus cause a number of adverse health effects, including reproductive and developmental problems, cancer, and damage to the immune system. Most of these toxic effects are mediated by the aryl hydrocarbon receptor. The toxicity of TCDD exhibits considerable interspecies variability.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages2
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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