TY - JOUR
T1 - 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng
AU - Fatmawati, Sri
AU - Ersam, Taslim
AU - Yu, Hongshan
AU - Zhang, Chunzhi
AU - Jin, Fengxie
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
We are thankful to International Research Collaboration and Scientific Publication, Directorate General of Higher Education (DGHE), Ministry of Education and Culture, Indonesia for financial support to Sri Fatmawati.
Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.
PY - 2014/9/15
Y1 - 2014/9/15
N2 - The root of Panax ginseng C. A. Meyer (Araliaceae) is a well-known herbal medicine in East Asia. The major bioactive metabolites in this root are commonly identified as ginsenosides. A series of ginsenosides were determined for in vitro human recombinant aldose reductase. This Letter aims to clarify the structural requirement for aldose reductase inhibition. We discovered that only ginsenoside 20(S)-Rh2 showed potent against aldose reductase, with an IC50of 147.3 μM. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in aldose reductase inhibition. An understanding of these requirements is considered necessary in order to develop a new type of aldose reductase inhibitor. Furthermore, P. ginseng might be an important herbal medicine in preventing diabetic complications.
AB - The root of Panax ginseng C. A. Meyer (Araliaceae) is a well-known herbal medicine in East Asia. The major bioactive metabolites in this root are commonly identified as ginsenosides. A series of ginsenosides were determined for in vitro human recombinant aldose reductase. This Letter aims to clarify the structural requirement for aldose reductase inhibition. We discovered that only ginsenoside 20(S)-Rh2 showed potent against aldose reductase, with an IC50of 147.3 μM. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in aldose reductase inhibition. An understanding of these requirements is considered necessary in order to develop a new type of aldose reductase inhibitor. Furthermore, P. ginseng might be an important herbal medicine in preventing diabetic complications.
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U2 - 10.1016/j.bmcl.2014.08.009
DO - 10.1016/j.bmcl.2014.08.009
M3 - Article
C2 - 25152999
AN - SCOPUS:84906967967
SN - 0960-894X
VL - 24
SP - 4407
EP - 4409
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 18
ER -
